Tau

2023

Tau and Neurodegeneration. Cytoskeleton (Hoboken). 2023 Dec 10. doi:10.1002/cm.21812. 

2021
The microglial P2Y(6) receptor mediates neuronal loss and memory deficits in neurodegeneration. Cell Rep. 2021 Dec 28;37(13):110148.

Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates. Sci Adv. 2021 Oct 22;7(43):eabg4980.

2020
Locus coeruleus pathology in progressive supranuclear palsy, and its relation to disease severity. Acta Neuropathol Commun. 2020 Feb 4;8(1):11.

2018
Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia. Cell Rep. 2018 Aug 21;24(8):1939-1948.e4.

2017
Astrocytes in mouse models of tauopathies acquire early deficits and lose neurosupportive functions. Acta Neuropathol Commun. 2017 Nov 29;5(1):89.

2013
Tau Pathology is Present In Vivo and Develops In Vitro in Sensory Neurons from Human P301S Tau Transgenic Mice: A System for Screening Drugs against Tauopathies. J Neurosci. 2013 Nov 13;33(46):18175-89.

2011
Presence of Reactive Microglia and Neuroinflammatory Mediators in a Case of Frontotemporal Dementia with P301S Mutation. Neurodegener Dis. 2011;8(4):221-9.

2010
Cell-mediated neuroprotection in a mouse model of human tauopathy. J Neurosci. 2010 Jul 28;30(30):9973-83.

2008
The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD family. Brain. 2008 Jan;131(Pt 1):72-89.

2004
Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein. Am J Pathol. 2004 Nov;165(5):1643-52.

2002
Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. J Neurosci. 2002 Nov 1;22(21):9340-51.

1998
Mutation in the tau gene in familial multiple system tauopathy with presenile dementia. Proc Natl Acad Sci USA. 1998 Jun 23; 95(13): 7737–7741.

1997
Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments. Proc Natl Acad Sci USA. 1997 Apr 15; 94(8): 4113–4118.

1992
Tau proteins of Alzheimer paired helical
filaments: abnormal phosphorylation of all six brain isoforms. Neuron. 1992 Jan;8(1):159-68.

1989
Multiple isoforms of human microtubule-associated protein tau: sequence and localization in neurofibrillary tangles of Alzheimer's disease. Neuron. 1989 Oct;3(4):519-26.

Alpha Synuclein

2024

The pathogenesis of Parkinson's disease. Lancet. 2024 Jan 20;403(10423):293-304. doi: 10.1016/S0140-6736(23)01478-2.

2023

New SNCA mutation and structures of α-synuclein filaments from juvenile-onset synucleinopathy. Acta Neuropathol. 2023 May;145(5):561-572. doi: 10.1007/s00401-023-02550-8.

Salivary α-Synuclein RT-QuIC Correlates with Disease Severity in de novo Parkinson's Disease. Mov Disord. 2023 Jan;38(1):153-155. doi: 10.1002/mds.29246.

2021
CSPα reduces aggregates and rescues striatal dopamine release in α-synuclein transgenic mice. Brain. 2021 Jul 28;144(6):1661-1669.

2019
Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson’s disease model. Acta Neuropathol. 2019 Oct;138(4):575-595.  

2017
The Transcellular Propagation and Intracellular Trafficking of α-Synuclein. Cold Spring Harb Perspect Med. 2017 Sep 1;7(9):a024380.

2016
Synaptic failure and α-synuclein. Mov Disord. 2016 Feb;31(2):169-77. 

2012
Genetic and Pathological links between Parkinson’s Disease and the lysosomal disorder Sanfilippo Syndrome. Mov Disord. 2012 Feb;27(2):312-5.  

Mechanisms underlying impairment of hippocampal long-term potentiation and memory in experimental Parkinson’s disease. Brain. 2012 Jun;135(Pt 6):1884-99.

2011
Induction of the unfolded protein response by α-synuclein in experimental models of Parkinson's disease. J Neurochem. 2011 Feb;116(4):588-605.

Dimebon does not ameliorate pathological changes caused by expression of truncated (1-120) human alpha-synuclein in dopaminergic neurons of transgenic mice. Neurodegener Dis. 2011;8(6):430-7.

Redistribution of DAT/α- synuclein complexes visualized by “in situ” proximity ligation assay in transgenic mice modelling early Parkinson’s disease. PLoS One. 2011;6(12):e27959.

2010
Progression of Parkinson’s disease pathology is reproduced by intragastric administration of rotenone in mice. PLoS One. 2010 Jan 19;5(1):e8762.

SNARE protein redistribution and synaptic failure in a mouse model of Parkinson’s disease. Brain. 2010 Jul;133(Pt 7):2032-44.

1998
α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies. Proc Natl Acad Sci USA. 1998 May 26;95(11):6469-73.

Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. Neurosci Lett. 1998 Jul 31;251(3):205-8. doi: 10.1016/s0304-3940(98)00504-7.

1997
α-Synuclein in Lewy bodies.Nature. 1997 Aug 28;388(6645):839-40.

1995

Assignment of human alpha-synuclein (SNCA) and beta-synuclein (SNCB) genes to chromosomes 4q21 and 5q35. Genomics. 1995 May 20;27(2):379-81. doi: 10.1006/geno.1995.1063.

1994

Identification of two distinct synucleins from human brain. FEBS Letters. 1994. Doi: 10.1016/0014-5793(94)00395-5.

Other

2024

Cleaved TMEM106B forms amyloid aggregates in central and peripheral nervous systems. Acta Neuropathol Commun. 2024. doi:10.1186/s40478-024-01813-z.

2022

Age-dependent formation of TMEM106B amyloid filaments in human brains. Nature. 2022 May;605(7909):310-314. doi: 10.1038/s41586-022-04650-z.

2013
Mixed tau, TDP-43 and p62 pathology in FTLD associated with a C9ORF72 repeat expansion and p.Ala239Thr MAPT (tau) variant. Acta Neuropathol. 2013 Feb;125(2):303-10.  

2010
Common Variants at 7p21 Associate with Frontotemporal Degeneration with TDP-43 Inclusions. Nat Genet. 2010 Mar;42(3):234-9.