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Spillantini Lab


Selected publications


The microglial P2Y(6) receptor mediates neuronal loss and memory deficits in neurodegeneration. Cell Rep. 2021 Dec 28;37(13):110148.

Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates. Sci Adv. 2021 Oct 22;7(43):eabg4980.

Locus coeruleus pathology in progressive supranuclear palsy, and its relation to disease severity. Acta Neuropathol Commun. 2020 Feb 4;8(1):11.

Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia. Cell Rep. 2018 Aug 21;24(8):1939-1948.e4.

Astrocytes in mouse models of tauopathies acquire early deficits and lose neurosupportive functions. Acta Neuropathol Commun. 2017 Nov 29;5(1):89.

Focal expression of mutant tau via AAV induces neurofibrillary tangle formation, neuronal loss, neuroinflammation and memory impairment in an APP mouse model. Neurobiol Aging. 2013 May;34(5):1355-68.

Tau Pathology is Present In Vivo and Develops In Vitro in Sensory Neurons from Human P301S Tau Transgenic Mice: A System for Screening Drugs against Tauopathies. J Neurosci. 2013 Nov 13;33(46):18175-89.

Presence of Reactive Microglia and Neuroinflammatory Mediators in a Case of Frontotemporal Dementia with P301S Mutation. Neurodegener Dis. 2011;8(4):221-9.

Cell-mediated neuroprotection in a mouse model of human tauopathy. J Neurosci. 2010 Jul 28;30(30):9973-83.

The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD family. Brain. 2008 Jan;131(Pt 1):72-89.

Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein. Am J Pathol. 2004 Nov;165(5):1643-52.

Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. J Neurosci. 2002 Nov 1;22(21):9340-51.

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia. Proc Natl Acad Sci USA. 1998 Jun 23; 95(13): 7737–7741.

Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments. Proc Natl Acad Sci USA. 1997 Apr 15; 94(8): 4113–4118.

Tau proteins of Alzheimer paired helical
filaments: abnormal phosphorylation of all six brain isoforms. 
Neuron. 1992 Jan;8(1):159-68.

Multiple isoforms of human microtubule-associated protein tau: sequence and localization in neurofibrillary tangles of Alzheimer's disease. Neuron. 1989 Oct;3(4):519-26.

Alpha Synuclein

CSPα reduces aggregates and rescues striatal dopamine release in α-synuclein transgenic mice. Brain. 2021 Jul 28;144(6):1661-1669.

Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson’s disease model. Acta Neuropathol. 2019 Oct;138(4):575-595.  

The Transcellular Propagation and Intracellular Trafficking of α-Synuclein. Cold Spring Harb Perspect Med. 2017 Sep 1;7(9):a024380.

Synaptic failure and α-synuclein. Mov Disord. 2016 Feb;31(2):169-77. 

Genetic and Pathological links between Parkinson’s Disease and the lysosomal disorder Sanfilippo Syndrome. Mov Disord. 2012 Feb;27(2):312-5.  

Mechanisms underlying impairment of hippocampal long-term potentiation and memory in experimental Parkinson’s disease. Brain. 2012 Jun;135(Pt 6):1884-99.

Induction of the unfolded protein response by α-synuclein in experimental models of Parkinson's disease. J Neurochem. 2011 Feb;116(4):588-605.

Dimebon does not ameliorate pathological changes caused by expression of truncated (1-120) human alpha-synuclein in dopaminergic neurons of transgenic mice. Neurodegener Dis. 2011;8(6):430-7.

Redistribution of DAT/α- synuclein complexes visualized by “in situ” proximity ligation assay in transgenic mice modelling early Parkinson’s disease. PLoS One. 2011;6(12):e27959.

Progression of Parkinson’s disease pathology is reproduced by intragastric administration of rotenone in mice. PLoS One. 2010 Jan 19;5(1):e8762.

SNARE protein redistribution and synaptic failure in a mouse model of Parkinson’s disease. Brain. 2010 Jul;133(Pt 7):2032-44.

α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies. Proc Natl Acad Sci USA. 1998 May 26;95(11):6469-73.

α-Synuclein in Lewy bodies.
Nature. 1997 Aug 28;388(6645):839-40.


Mixed tau, TDP-43 and p62 pathology in FTLD associated with a C9ORF72 repeat expansion and p.Ala239Thr MAPT (tau) variant. Acta Neuropathol. 2013 Feb;125(2):303-10.  

Common Variants at 7p21 Associate with Frontotemporal Degeneration with TDP-43 Inclusions. Nat Genet. 2010 Mar;42(3):234-9.